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Impact of significant mitral regurgitation on mortality in patients without ischemic cardiomyopathy treated with transfemoral TAVI

Session Poster Session 1

Speaker Alfredo Chauca Tapia

Event : Acute Cardiovascular Care 2019

  • Topic : interventional cardiology and cardiovascular surgery
  • Sub-topic : Interventional Cardiology - Other
  • Session type : Poster Session

Authors : A Chauca Tapia (Cadiz,ES), I Noval Morillas (Cadiz,ES), E Izaga Torralba (Cadiz,ES), F Garcias Lanzas (Cadiz,ES), A Gutierrez Barrios (Cadiz,ES), G Calle Perez (Cadiz,ES), R Vazquez Garcia (Cadiz,ES)

A Chauca Tapia1 , I Noval Morillas1 , E Izaga Torralba1 , F Garcias Lanzas1 , A Gutierrez Barrios1 , G Calle Perez1 , R Vazquez Garcia1 , 1University Hospital Puerta del Mar, Cardiology - Cadiz - Spain ,


The aim of this study is analyze the impact of significant mitral regurgitation (MR) in patients diagnosed of severe aortic stenosis wihout ischemic heart disease treated with transfemoral TAVI.
Methods and results:
This is a retrospecive study of patiens with severe aortic steneosis (AS) treated with transfemoral TAVI between 2011 and 2018 in tertiary hospital. Significant mitral regurgitation was defined as moderate or severe MR assessed by 2D transthoracic echocardiography.
From the patients that were included in our study, 54.8% (90/164) did not have ischemic heart disease and from this group 23.3% (21/90) had significant MR. The statistically significant differences between patiens with and without significant MR were left ventricular ejection fraction (LVEF) (53.05%vs60.6%;p=0.02), the prevalence of hypertension (92.2%vs71.4%;p=0.02) and mortality (19%vs2.9%;p=0.025) as it is showed in the table 1. When we perfom a survival analysis , it is objectified that patients with significant MR have a lower suvival but without reaching statistical significance (p=0.07) (Figure 1).
The results of our study show that a significant MR clearly affects the mortality of patients with no history of ischemic heart disease who  who underwent transfemoral TAVI.

Significant MR (n=21) Non significant MR (n=69) p value
Mean age 80.5 79.94 0.9
Female/Male 81%/19% 71%/29% 0.2
LVEF (%) 53.05 60.6 0.02
Mean gradient (mmHg) 50.85 49.98 0.8
Hypertension 95.23% 71.02% 0.02
DM 28.6% 31.89% 0.8
Dyslipidemia 38.1% 49.27% 0.5
Chronic kidney disease 42.85% 57.98% 0.12
Mortality 19.05% 2.9% 0.025

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