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Association with coronary high-intensity plaque on T1-weighted magnetic resonance imaging and circulating levels of malondialdehyde-modified low-density lipoprotein
Authors : D Hiraya (Tsukuba,JP), A Sato (Tsukuba,JP), T Hoshi (Tsukuba,JP), T Ichinohe (Tsukuba,JP), S Sakai (Tsukuba,JP), H Watabe (Tsukuba,JP), M Ieda (Tsukuba,JP)
D. Hiraya1
,
A. Sato1
,
T. Hoshi1
,
T. Ichinohe1
,
S. Sakai1
,
H. Watabe1
,
M. Ieda1
,
1Cardiovascular Division, Faculty of Medicine, University of Tsukuba - Tsukuba - Japan
,
Topic(s): Cardiac Magnetic Resonance: Coronary Imaging
Objectives: This study aimed to evaluate the association with coronary high-intensity plaque (HIP) on non-contrast T1-weighted magnetic resonance imaging (T1WI) and circulating levels of malondialdehyde-modified low-density lipoprotein (MDA-LDL).
Methods: A total of 139 patients with coronary artery stenosis (>70%) were imaged with non-contrast T1WI by using a 1.5-T magnetic resonance system (HIP: n=60, non-HIP: n=79). HIP was defined as a signal intensity of coronary plaque to cardiac muscle ratio (PMR) of ≥1.4. At admission, circulating levels of MDA-LDL and other lipid-related markers (triglyceride, HDL, LDL, Lp(a), RLP-C, and EPA/AA) were measured.
Results: Circulating levels of MDA-LDL (p=0.001) and LDL (p=0.041) were significantly higher in patients with HIP than those without, whereas the other lipid-related markers were not significantly different between both groups. In multivariable logistic regression analysis, MDA-LDL levels were independently associated with the presence of HIP (OR 1.03; 95% CI, 1.00–1.06, p=0.015) after adjusting for cofounding factors (age, sex, triglyceride, LDL, Lp(a), RLP-C, and EPA/AA). The optimal MDA-LDL threshold for predicting coronary HIP was 90.4 U/L, identified by the receiver operating characteristic curve.
Conclusion: MDA-LDL levels might be associated with the presence of HIP in patients with coronary artery disease.
ESC Professional Members, Association Members (Ivory & above) benefit from year-round access to all the resources from their respective Association, and to all content from previous years. Fellows of the ESC (FESC), and professionals in training or under 40 years old, who subscribed to a Young Combined Membership package benefit from access to all ESC 365 content from all events, all editions, all year long. Find out more about ESC Memberships here.
