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One-hour rule-out and rule-in of acute myocardial infarction using a novel high-sensitivity cardiac troponin I assay

Session Poster session 5

Speaker Raphael Twerenbold

Event : ESC Congress 2017

  • Topic : coronary artery disease, acute coronary syndromes, acute cardiac care
  • Sub-topic : Non-ST-Elevation Myocardial Infarction (NSTEMI)
  • Session type : Poster Session

Authors : R Twerenbold (Basel,CH), J Boeddinghaus (Basel,CH), T Nestelberger (Basel,CH), M Rubini Gimenez (Basel,CH), C Puelacher (Basel,CH), O Miro (Barcelona,ES), FJ Martin-Sanchez (Madrid,ES), B Morawiec (Katowice,PL), S Osswald (Basel,CH), T Reichlin (Basel,CH), C Mueller (Basel,CH)

R. Twerenbold1 , J. Boeddinghaus1 , T. Nestelberger1 , M. Rubini Gimenez1 , C. Puelacher1 , O. Miro2 , F.J. Martin-Sanchez3 , B. Morawiec4 , S. Osswald1 , T. Reichlin1 , C. Mueller1 , 1University Hospital Basel - Basel - Switzerland , 2Hospital Clinic de Barcelona - Barcelona - Spain , 3Hospital Clinic San Carlos - Madrid - Spain , 4Medical University of Silesia, Cardiology department - Katowice - Poland ,

European Heart Journal ( 2017 ) 38 ( Supplement ), 1006

Background: The European Society of Cardiology suggests the use of a 0/1h-algorithm for rapid rule-out and rule-in of acute myocardial infarction (AMI) when using high-sensitivity cardiac troponin (hs-cTn).

Purpose: We aimed to derive and validate a new 0/1h-algorithm for a novel hs-cTnI assay.

Methods: In a prospective international multicentre diagnostic study enrolling patients presenting with suspected AMI to the ED, hs-cTnI was determined at baseline and after one hour using Centaur hs-cTnI. Patients presenting with STEMI were excluded. The final diagnosis was centrally adjudicated by two independent cardiologists using all available data including coronary angiography, echocardiography, follow-up data, and serial measurements of hs-cTnT (but not hs-cTnI). The hs-cTnI 0/1h-algorithm, incorporating measurements performed at baseline and absolute changes within 1 hour, was derived in a randomly selected sample of 672 patients (derivation sample) using classification and regression tree (CART) analysis, and then validated in the remaining 675 patients (validation sample).

Results: Acute myocardial infarction was the final diagnosis in 18% of the 1347 recruited patients. After applying the hs-cTnI 0/1h-algorithm developed in the derivation cohort to the validation cohort, 46% of patients could be classified as “rule-out”, 18% as “rule-in”, and 36% as “observe” (Figure 1). In the validation cohort, the derived rule-out strategy resulted in a negative predictive value for AMI of 99.7% (95% confidence interval (CI), 97.8–100%) and a sensitivity of 99.1% (95% CI, 95.3–100%) while the derived rule-in strategy resulted in a positive predictive value for AMI of 72.5% (95% CI, 63.6–80.3%) and a specificity of 94.1% (95% CI, 91.8–95.9%).

Conclusion: Using a simple algorithm incorporating baseline hs-cTnI values and the absolute change within the first hour, measured with a novel hs-cTnI assay, allows very safe rule-out as well as accurate rule-in of AMI in two patients out of three presenting with suspected AMI.

Figure 1

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