In order to bring you the best possible user experience, this site uses Javascript. If you are seeing this message, it is likely that the Javascript option in your browser is disabled. For optimal viewing of this site, please ensure that Javascript is enabled for your browser.

The free consultation period for this content is over.

It is now only available year-round to ESC Professional Members, Fellows of the ESC, and Young combined Members

Serum uromodulin predicts a decline in kidney function independently from the presence of type 2 diabetes

Session Poster session 6

Speaker Christoph Saely

Event : ESC Congress 2017

  • Topic : coronary artery disease, acute coronary syndromes, acute cardiac care
  • Sub-topic : Acute Coronary Syndromes: Biomarkers
  • Session type : Poster Session

Authors : A Leiherer (Feldkirch,AT), A Muendlein (Feldkirch,AT), CH Saely (Triesen,LI), EM Brandtner (Feldkirch,AT), K Geiger (Feldkirch,AT), A Schuler (Feldkirch,AT), P Schwerzler (Triesen,LI), A Mader (Triesen,LI), P Fraunberger (Feldkirch,AT), H Drexel (Philadelphia,US)

Authors:
A. Leiherer1 , A. Muendlein1 , C.H. Saely2 , E.M. Brandtner1 , K. Geiger1 , A. Schuler3 , P. Schwerzler2 , A. Mader2 , P. Fraunberger4 , H. Drexel5 , 1VIVIT Institute - Feldkirch - Austria , 2Private University of the Principality of Liechtenstein - Triesen - Liechtenstein , 3Academic Teaching Hospital, Department of Medicine and Cardiology - Feldkirch - Austria , 4Medical Central Laboratory - Feldkirch - Austria , 5Drexel University College of Medicine - Philadelphia - United States of America ,

Citation:
European Heart Journal ( 2017 ) 38 ( Supplement ), 1128

Introduction: Uromodulin is the most abundant protein excreted in urine. Low uromodulin has been found to be associated with type 2 diabetes (T2DM) as well as with chronic kidney disease (CKD).

Purpose: The purpose of this study was to investigate whether serum uromodulin also predicts a future decline in kidney function.

Methods: We measured serum uromodulin in 529 patients undergoing coronary angiography for the evaluation of established or suspected coronary artery disease (CAD).

Results: Uromodulin was lower in patients with T2DM than in nondiabetic subjects (148±70 vs. 171±79; p=0.001) and significantly correlated with estimated glomerular filtration rate (eGFR; r=0.242, p<0.001) and, inversely, with the albumin creatinine ratio (ACR; r=-0.120, p=0.012). It was significantly lower in patients with CKD (eGFR <60 ml/min/1.73 m2) than in those with normal kidney function (72±29 vs. 169±76 ng/ml; p<0.001), and also in patients with albuminuria than in patients without increased albumin excretion (149±72 vs. 168±78 ng/ml; p=0.008). Further, uromodulin at baseline was significantly lower in patients who developed an eGFR <60 ml/min/1.73 m2 during 4 years of follow-up compared to those who did not (127±42 vs. 180±79ng/ml, p=0.003). It was inversely associated with declining eGFR even after full adjustment including ACR, baseline CAD and the presence of T2DM (OR=0.354 [95% CI 0.131–0.957], p=0.041). The inclusion of uromodulin to a basic prediction model for CKD increased the model performance (C-statistic 0.844 vs. 0.804, p=0.049).

Conclusion: In conclusion, we for the first time show that serum uromodulin predicts a decline in kidney function independently from conventional risk factors including T2DM.

Members get more

Join now
  • 1ESC Professional Members – access all resources from general ESC events 
  • 2ESC Association Members (Ivory, Silver, Gold) – access your Association’s resources
  • 3Under 40 or in training - with a Combined Membership, access all resources
Join now

Our sponsors

ESC 365 is supported by Bayer, Boehringer Ingelheim and Lilly Alliance, Bristol-Myers Squibb and Pfizer Alliance, Novartis Pharma AG and Vifor Pharma in the form of educational grants. The sponsors were not involved in the development of this platform and had no influence on its content.

logo esc

Our mission: To reduce the burden of cardiovascular disease

Who we are