In order to bring you the best possible user experience, this site uses Javascript. If you are seeing this message, it is likely that the Javascript option in your browser is disabled. For optimal viewing of this site, please ensure that Javascript is enabled for your browser.

The free consultation period for this content is over.

It is now only available year-round to ESC Professional Members, Fellows of the ESC, and Young combined Members

Left ventricular longitudinal strain impairment predicts cardiovascular events in asymptomatic type 1 myotonic dystrophy

Session Poster session 7

Speaker Nicolas Bidegain

Event : ESC Congress 2017

  • Topic : imaging
  • Sub-topic : Systolic and Diastolic Function
  • Session type : Poster Session

Authors : R Garcia (Poitiers,FR), M Rehman (Poitiers,FR), C Goujeau (Poitiers,FR), B Degand (Poitiers,FR), F Le Gal (Poitiers,FR), Q Labarre (Poitiers,FR), N Bidegain (Poitiers,FR), L Christiaens (Poitiers,FR), C Bouleti (Paris,FR)

R. Garcia1 , M. Rehman1 , C. Goujeau1 , B. Degand1 , F. Le Gal1 , Q. Labarre1 , N. Bidegain1 , L. Christiaens1 , C. Bouleti2 , 1University Hospital of Poitiers, Department of cardiology - Poitiers - France , 2Hospital Bichat-Claude Bernard - Paris - France ,

Echocardiography - Ventricular and atrial function

European Heart Journal ( 2017 ) 38 ( Supplement ), 1293

Background: Type 1 myotonic dystrophy (DM1) patients' prognosis is very poor and is marked by respiratory and cardiac complications. Up until now, only a few prognostic factors for cardiovascular events have been identified, and they are predictive of end-stage disease.

Objectives: To assess the prognostic value of global longitudinal strain (GLS) for cardiovascular events in asymptomatic DM1 patients.

Methods: DM1 patients were included between 2011 and 2015 and followed up until January 2016. Patients underwent a transthoracic echocardiography at inclusion. The primary endpoint was a composite of all-cause mortality, type 2 Mobitz 2 and type 3 atrioventricular block, symptomatic sino-atrial block, HV interval ≥70 ms at invasive electrophysiology exploration, LVEF ≤45% and newly developed atrial fibrillation.

Results: Forty-six patients (25 males, mean age 40 years old) were included. The primary outcome was reached in 14 patients with a mean follow-up of 38 months. GLS of patients who reached the primary endpoint was significantly impaired as compared to those who did not (-15.1 [-16.7; -12.7] vs. -18.2 [-19.2; -16.7] respectively; P=0.001). According to ROC curve analysis, probability of primary outcome occurrence was significantly greater in patients with GLS values ≥ -17.2% (P=0.001). On multivariate analysis, PR electrocardiogram interval and GLS remained significantly and independently associated with the primary endpoint [hazard ratio (HR) 1.03, 95% confidence interval (CI) 1.01–1.04, P=0.006] for PR interval; HR 1.4, 95% CI 1.1–1.7, P=0.002 for GLS] while LVEF alone was not.

Conclusion: Left ventricular GLS is a powerful marker to predict cardiovascular events in asymptomatic DM1 patients, independently of LVEF.

Survival probability

Get your access to resources

Join now
  • 1ESC Professional Members – access all ESC Congress resources 
  • 2ESC Association Members (Ivory, Silver, Gold) – access your Association’s resources
  • 3Under 40 or in training - with a Combined Membership, access all resources
Join now
logo esc

Our mission: To reduce the burden of cardiovascular disease

Who we are